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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735404
Species: Homo sapiens
RGD Object: Gene
Symbol: ALB
Name: albumin
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALBaffects bindingEXP 6480464CTDMercuric Chloride binds to ALB proteinPMID:17489621
ALBdecreases expressionISOAlb (Rattus norvegicus)6480464CTDMercuric Chloride results in decreased expression of ALB proteinPMID:24485406
ALBincreases expressionISOAlb (Mus musculus)6480464CTDMercuric Chloride results in increased expression of ALB proteinPMID:37172713
ALBincreases expressionISOAlb (Rattus norvegicus)6480464CTDMercuric Chloride results in increased expression of ALB proteinPMID:21549428
ALBmultiple interactionsISOAlb (Rattus norvegicus)6480464CTD[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]; Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]PMID:17657459 PMID:24485406
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