Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	732740
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CAT
Name:	catalase

Acc ID:	CHEBI:31823
Term:	mercury dichloride
Definition:	A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID:	MESH:D008627

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CAT	decreases expression	EXP		6480464	CTD	Mercuric Chloride results in decreased expression of CAT protein	PMID:20629087
CAT	multiple interactions	EXP		6480464	CTD	mangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein]	PMID:20629087
CAT	affects activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Mercuric Chloride affects the activity of CAT protein	PMID:22351102 PMID:24555655
CAT	decreases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Mercuric Chloride results in decreased activity of CAT protein	PMID:19427169 PMID:20820944 PMID:21787585 PMID:22416658 PMID:23369933 PMID:24485406 PMID:24751971 PMID:25368988 PMID:25600690 PMID:26215012 PMID:26825963 PMID:33460233
CAT	decreases activity	ISO	Cat (Mus musculus)	6480464	CTD	Mercuric Chloride results in decreased activity of CAT protein	PMID:21259295
CAT	decreases expression	ISO	Cat (Rattus norvegicus)	6480464	CTD	Mercuric Chloride results in decreased expression of CAT protein	PMID:24970117
CAT	decreases expression	ISO	Cat (Mus musculus)	6480464	CTD	Mercuric Chloride results in decreased expression of CAT protein	PMID:37172713
CAT	increases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Mercuric Chloride results in increased activity of CAT protein	PMID:15977196 PMID:17516994
CAT	increases expression	ISO	Cat (Rattus norvegicus)	6480464	CTD	Mercuric Chloride results in increased expression of CAT protein	PMID:15977196
CAT	multiple interactions	ISO	Cat (Rattus norvegicus)	6480464	CTD	[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased activity of CAT protein; [Vitamin E co-treated with Sodium Selenite] inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; [zinc chloride co-treated with Sodium Selenite] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; allyl sulfide inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Mercuric Chloride results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Selenium inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]]; Sodium Selenite inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased activity of CAT protein]; Sodium Selenite inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]	PMID:17516994 PMID:21787585 PMID:22416658 PMID:23369933 PMID:24485406 PMID:24751971 PMID:25600690 PMID:26215012 PMID:26825963 PMID:33460233 PMID:36646412
CAT	multiple interactions	ISO	Cat (Mus musculus)	6480464	CTD	[Mercuric Chloride co-treated with diphenyldiselenide] results in decreased activity of CAT protein	PMID:21259295

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