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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDMercuric Chloride results in decreased expression of SOD2 mRNAPMID:24751971 PMID:33460233
SOD2increases activityISOSod2 (Rattus norvegicus)6480464CTDMercuric Chloride results in increased activity of SOD2 proteinPMID:15977196
SOD2increases expressionISOSod2 (Mus musculus)6480464CTDMercuric Chloride results in increased expression of SOD2 proteinPMID:9374288
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDMercuric Chloride results in increased expression of SOD2 mRNA; Mercuric Chloride results in increased expression of SOD2 proteinPMID:15977196 PMID:21232032 PMID:23415682
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Mercuric Chloride results in increased expression of SOD2 protein]; Mercuric Chloride results in decreased activity of and results in increased reduction of SOD2 protein; Mercuric Chloride results in increased expression of and results in increased activity of SOD2 proteinPMID:12111001 PMID:9374288
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTDBerberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]PMID:24751971 PMID:33460233
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