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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDMercuric Chloride results in increased expression of HSPA1A mRNAPMID:16324719 PMID:17244614
HSPA1Amultiple interactionsEXP 6480464CTD[Mercuric Chloride results in increased abundance of Reactive Oxygen Species] which results in increased expression of HSPA1A mRNA; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of HSPA1A mRNA]; Mercuric Chloride promotes the reaction [HSF1 protein binds to HSPA1A promoter]; Selenomethionine inhibits the reaction [Mercuric Chloride results in increased expression of HSPA1A mRNA]PMID:16324719 PMID:17244614
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDMercuric Chloride results in increased expression of HSPA1A mRNAPMID:16507785
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