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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:3179
Term: bromobenzene
Definition: The simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.
Chemical ID: MESH:C032036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbromobenzene results in increased expression of HMOX1 mRNA, bromobenzene results in increased expression of HMOX1 protein

PMID:12628495, PMID:15056800, PMID:15976192, PMID:3343248
multiple interactionsEXP 6480464CTD[bromobenzene co-treated with EGLN1 mutant form] results in increased expression of HMOX1 mRNA

PMID:24190904
increases expressionISORGD:107176480464CTDbromobenzene results in increased expression of HMOX1 protein

PMID:18078705
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.