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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:31781
Term: lopinavir
Definition: A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.
Chemical ID: MESH:D061466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISORGD:7309016480464CTDLopinavir results in increased expression of HMOX1 mRNA Lopinavir results in increased expression of HMOX1 protein

PMID:26968795
Hmox1multiple interactionsISORGD:7309016480464CTDLopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin] Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]

PMID:26968795
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