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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735449
Species: Mus musculus
RGD Object: Gene
Symbol: Vamp2
Name: vesicle-associated membrane protein 2
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vamp2multiple interactionsEXP 6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of VAMP2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of VAMP2 proteinPMID:35367965
Vamp2affects expressionISOVamp2 (Rattus norvegicus)6480464CTDlead acetate affects the expression of VAMP2 mRNAPMID:27984133
Vamp2affects localizationISOVamp2 (Rattus norvegicus)6480464CTDlead acetate affects the localization of VAMP2 proteinPMID:22265330
Vamp2decreases expressionISOVamp2 (Rattus norvegicus)6480464CTDlead acetate results in decreased expression of VAMP2 proteinPMID:20375082
Vamp2multiple interactionsISOVamp2 (Rattus norvegicus)6480464CTD2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [lead acetate affects the localization of VAMP2 protein]; [[lead acetate results in increased abundance of Lead] which results in increased expression of MIR34B mRNA] which results in decreased expression of VAMP2 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of VAMP2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of VAMP2 protein; BDNF protein inhibits the reaction [lead acetate results in decreased expression of VAMP2 protein]PMID:20375082 PMID:22265330 PMID:35367965
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