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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731784
Species: Homo sapiens
RGD Object: Gene
Symbol: GRIN1
Name: glutamate ionotropic receptor NMDA type subunit 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GRIN1decreases expressionISOGrin1 (Mus musculus)6480464CTDlead acetate results in decreased expression of GRIN1 mRNA; lead acetate results in decreased expression of GRIN1 proteinPMID:24260418 PMID:25242007
GRIN1decreases expressionISOGrin1 (Rattus norvegicus)6480464CTDlead acetate results in decreased expression of GRIN1 mRNA; lead acetate results in decreased expression of GRIN1 proteinPMID:20381573 PMID:22160880
GRIN1multiple interactionsISOGrin1 (Rattus norvegicus)6480464CTD[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein; Choline analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 mRNA]; Choline analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 protein]; lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]PMID:12480136 PMID:20381573
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