RGD Gene Chemical Interaction Report

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	70332
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Hif3a
Name:	hypoxia inducible factor 3 subunit alpha

Acc ID:	CHEBI:31767
Term:	lead diacetate
Definition:	A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID:	MESH:C008261

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	lead acetate results in increased expression of HIF3A mRNA	PMID:22641619
decreases expression	ISO	RGD:732650	6480464	CTD	lead acetate results in decreased expression of HIF3A mRNA	PMID:21829687

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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