GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | increases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | lead acetate results in increased expression of PPARG protein | PMID:28283887 | Pparg | multiple interactions | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of PPARG protein] which results in decreased expression of GFAP protein; [lead acetate co-treated with Cadmium Chloride] results in increased expression of PPARG protein; [lead acetate co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased expression of PPARG protein; [lead acetate co-treated with sodium arsenite] results in increased expression of PPARG protein; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [PPARG protein binds to GFAP promoter]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of PPARG protein; CR8 compound analog inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]; CR8 compound inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of PPARG protein]; PPARG protein affects the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of and results in increased cleavage of PARP1 protein]; PPARG protein affects the reaction [lead acetate results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]; T 0070907 inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of PPARG protein]; T 0070907 inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of PPARG protein] | PMID:24481447 PMID:28283887 | | ||||||||||||||||||||||
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