GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP9 | increases activity | ISO | Casp9 (Mus musculus) | 6480464 | CTD | lead acetate results in increased activity of CASP9 protein | PMID:27236077 | CASP9 | increases expression | ISO | Casp9 (Rattus norvegicus) | 6480464 | CTD | lead acetate results in increased expression of CASP9 mRNA | PMID:23906897 | CASP9 | increases expression | ISO | Casp9 (Mus musculus) | 6480464 | CTD | lead acetate results in increased expression of CASP9 protein | PMID:27604105 | CASP9 | multiple interactions | ISO | Casp9 (Rattus norvegicus) | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein; Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein]; IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate results in increased expression of CASP9 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP9 mRNA]]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP9 mRNA] | PMID:23906897 PMID:26396915 PMID:33242459 | CASP9 | multiple interactions | ISO | Casp9 (Mus musculus) | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; MIR671 mRNA inhibits the reaction [lead acetate results in increased expression of CASP9 protein]; PPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP9 protein] | PMID:27236077 PMID:27604105 PMID:37397918 | | ||||||||||||||||||||||
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