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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Syn1
Name: synapsin I
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Syn1decreases expressionEXP 6480464CTDlead acetate results in decreased expression of SYN1 proteinPMID:17047031
Syn1decreases phosphorylationEXP 6480464CTDlead acetate results in decreased phosphorylation of SYN1 proteinPMID:30121340
Syn1increases expressionISOSyn1 (Mus musculus)6480464CTDlead acetate results in increased expression of SYN1 mRNAPMID:24260418
Syn1multiple interactionsISOSYN1 (Homo sapiens)6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein]PMID:36096218
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