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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:31746
Term: kainic acid
Definition: A pyrrolidinecarboxylic acid that has formula C10H15NO4.
Chemical ID: MESH:D007608
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDKainic Acid results in increased activity of CASP3 proteinPMID:16469440
Casp3increases cleavageEXP 6480464CTDKainic Acid results in increased cleavage of CASP3 proteinPMID:25453207
Casp3increases expressionEXP 6480464CTDKainic Acid results in increased expression of CASP3 proteinPMID:35544363
Casp3multiple interactionsEXP 6480464CTD4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]; Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]PMID:16469440 PMID:25453207 PMID:35544363
Casp3increases activityISOCasp3 (Rattus norvegicus)6480464CTDKainic Acid results in increased activity of CASP3 proteinPMID:31430510
Casp3increases expressionISOCasp3 (Rattus norvegicus)6480464CTDKainic Acid results in increased expression of CASP3 mRNA; Kainic Acid results in increased expression of CASP3 proteinPMID:18711747 PMID:19700661
Casp3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDoridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]PMID:31430510
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDEPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]PMID:18711747
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