Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	730870
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CYP1A1
Name:	cytochrome P450 family 1 subfamily A member 1

Acc ID:	CHEBI:31695
Term:	indigo carmine
Definition:	An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow.
Chemical ID:	MESH:D007203

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CYP1A1	increases activity	EXP		6480464	CTD	Indigo Carmine results in increased activity of CYP1A1 protein	PMID:18493746
CYP1A1	multiple interactions	EXP		6480464	CTD	Indigo Carmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]	PMID:18493746
CYP1A1	increases activity	ISO	Cyp1a1 (Rattus norvegicus)	6480464	CTD	Indigo Carmine results in increased activity of CYP1A1 protein	PMID:18493746
CYP1A1	increases expression	ISO	Cyp1a1 (Mus musculus)	6480464	CTD	Indigo Carmine results in increased expression of CYP1A1 mRNA	PMID:15882963
CYP1A1	increases expression	ISO	Cyp1a1 (Rattus norvegicus)	6480464	CTD	Indigo Carmine results in increased expression of CYP1A1 mRNA	PMID:15001395
CYP1A1	multiple interactions	ISO	Cyp1a1 (Rattus norvegicus)	6480464	CTD	Indigo Carmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]	PMID:18493746

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