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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:31687
Term: idebenone
Definition: A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Chemical ID: MESH:C036619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAdecreases expressionISOPpara (Rattus norvegicus)6480464CTDidebenone results in decreased expression of PPARA proteinPMID:28648635
PPARAmultiple interactionsISOPpara (Rattus norvegicus)6480464CTDidebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]PMID:28648635
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