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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737121
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn5increases expressionISOCCN5 (Homo sapiens)6480464CTDFulvestrant results in increased expression of CCN5 mRNAPMID:31646340
Ccn5multiple interactionsISOCCN5 (Homo sapiens)6480464CTDCadmium inhibits the reaction [Fulvestrant results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [bisphenol S results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCN5 mRNA]PMID:10944450 PMID:17872378 PMID:29389661 PMID:31646340
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