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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733179
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNB1
Name: cyclin B1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNB1increases expressionEXP 6480464CTDfulvestrant results in increased expression of CCNB1 mRNAPMID:12154049
CCNB1multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of CCNB1 mRNA]PMID:17445807
CCNB1decreases expressionISOCcnb1 (Rattus norvegicus)6480464CTDfulvestrant results in decreased expression of CCNB1 mRNAPMID:21980073
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