GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gper1 | multiple interactions | EXP | | 6480464 | CTD | GPER1 protein affects the reaction [[fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; GPER1 protein affects the reaction [[fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA] | PMID:28446726 | Gper1 | affects response to substance | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | GPER1 protein affects the susceptibility to fulvestrant | PMID:24440569 | Gper1 | decreases response to substance | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | GPER1 mutant form results in decreased susceptibility to fulvestrant | PMID:24169358 | Gper1 | increases expression | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | Fulvestrant results in increased expression of GPER1 mRNA; Fulvestrant results in increased expression of GPER1 protein | PMID:25969534 PMID:28882636 PMID:31646340 | Gper1 | multiple interactions | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Fulvestrant results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [Cadmium results in decreased expression of GPER1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; GPER1 protein affects the reaction [Fulvestrant affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Fulvestrant promotes the reaction [CAPN1 protein results in increased cleavage of and results in increased activity of CAPN1 protein]]; GPER1 protein promotes the reaction [Fulvestrant results in increased expression of ESRRA mRNA] | PMID:20211987 PMID:24440569 PMID:25969534 PMID:26470790 PMID:27880919 PMID:28882636 PMID:30195206 PMID:31646340 | | ||||||||||||||||||||||
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