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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620018
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gzmb
Name: granzyme B
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gzmbdecreases expressionISOGZMB (Homo sapiens)6480464CTDfulvestrant results in decreased expression of GZMB mRNA; fulvestrant results in decreased expression of GZMB proteinPMID:20145137
Gzmbincreases expressionISOGZMB (Homo sapiens)6480464CTD[fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNAPMID:20145137
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