Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species:
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [gypenoside analog results in increased expression of and results in increased activity of HMOX1 protein], fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein], fulvestrant inhibits the reaction [Phytoestrogens results in increased expression of and results in increased activity of HMOX1 protein], fulvestrant inhibits the reaction [resveratrol results in increased expression of HMOX1 protein]

PMID:21192278, PMID:24437944, PMID:24726523
decreases expressionISORGD:7309016480464CTDfulvestrant results in decreased expression of HMOX1 mRNA

PMID:16298037
multiple interactionsISORGD:7309016480464CTDfulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA], fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]

PMID:19781563
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.