Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDFulvestrant results in increased expression of CYP1A1 mRNAPMID:19901195 PMID:28985473 PMID:31646340
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]PMID:12093619
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[Fulvestrant results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; Fulvestrant inhibits the reaction [daidzein results in decreased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1A1 protein]; Fulvestrant inhibits the reaction [Genistein results in decreased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA]; Fulvestrant promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:10619402 PMID:19460354 PMID:19901195 PMID:21513769 PMID:28618207 PMID:28985473 PMID:31646340
Go Back to source page   Continue to Ontology report