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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2multiple interactionsEXP 6480464CTDEGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]PMID:25813982
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDfulvestrant results in increased expression of ABCC2 proteinPMID:24685904
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of ABCC2 gene; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC2 protein]; Fulvestrant inhibits the reaction [Genistein results in increased expression of ABCC2 protein]PMID:24685904 PMID:31601247
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