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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2253
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100g
Name: S100 calcium binding protein G
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [2, 2', 4, 4'-tetrabromodiphenyl ether results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [2, 2', 4, 4'-tetrabromodiphenyl ether results in increased expression of S100G protein], fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G protein], fulvestrant inhibits the reaction [butylparaben results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [butylparaben results in increased expression of S100G protein], fulvestrant inhibits the reaction [Estradiol results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [Estradiol results in increased expression of S100G protein], fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of S100G protein], fulvestrant inhibits the reaction [isobutylparaben results in increased expression of S100G protein], fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of S100G protein], fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [octylphenol results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [Triclosan results in increased expression of S100G mRNA], fulvestrant inhibits the reaction [Triclosan results in increased expression of S100G protein]

PMID:17361017, PMID:17504770, PMID:19654335, PMID:22062131, PMID:23211298, PMID:23261820
multiple interactionsISORGD:13323556480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G mRNA], Fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G protein], Fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G mRNA], Fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G protein], Fulvestrant inhibits the reaction [octylphenol results in increased expression of S100G mRNA], Fulvestrant inhibits the reaction [octylphenol results in increased expression of S100G protein], Fulvestrant inhibits the reaction [Progesterone results in increased expression of S100G mRNA]

PMID:15509668
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.