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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2149
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Areg
Name: amphiregulin
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aregdecreases expressionISOAREG (Homo sapiens)6480464CTDFulvestrant results in decreased expression of AREG mRNAPMID:16202921 PMID:16514628 PMID:26865669 PMID:31646340
Aregincreases expressionISOAREG (Homo sapiens)6480464CTDfulvestrant results in increased expression of AREG mRNAPMID:15072547
Aregmultiple interactionsISOAREG (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of AREG mRNA]; Fulvestrant inhibits the reaction [arsenite results in increased expression of AREG mRNA]; Fulvestrant inhibits the reaction [Cadmium results in increased expression of AREG mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of AREG mRNA]PMID:31059536 PMID:31646340
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