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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityISORGD:7368326480464CTDfulvestrant affects the activity of EGF protein

PMID:19395996
multiple interactionsISORGD:25426480464CTDEGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]

PMID:25813982
multiple interactionsISORGD:7368326480464CTDfulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein], fulvestrant inhibits the reaction [EGF protein results in increased expression of TFF1 mRNA]

PMID:19395996, PMID:19593637, PMID:20206645
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.