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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733595
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB2
Name: adrenoceptor beta 2
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADRB2affects expressionEXP 6480464CTDFormoterol Fumarate affects the expression of ADRB2 mRNAPMID:24705868
ADRB2increases activityEXP 6480464CTDFormoterol Fumarate results in increased activity of ADRB2 proteinPMID:34601065
ADRB2increases phosphorylationEXP 6480464CTDFormoterol Fumarate results in increased phosphorylation of ADRB2 proteinPMID:14722251 PMID:16980553
ADRB2multiple interactionsEXP 6480464CTD[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]; Formoterol Fumarate binds to and results in increased activity of ADRB2 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Formoterol Fumarate promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]PMID:14730417 PMID:16980553 PMID:24705868
ADRB2multiple interactionsISOAdrb2 (Mus musculus)6480464CTDFormoterol Fumarate binds to and results in increased activity of ADRB2 proteinPMID:20061444
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