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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6v1
Name: cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
Acc ID: CHEBI:31622
Term: flunitrazepam
Definition: A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Chemical ID: MESH:D005445
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6v1increases metabolic processingISORGD:7374166480464CTDCYP2C19 protein results in increased metabolism of Flunitrazepam

PMID:10911933
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.