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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61855
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Acc ID: CHEBI:31622
Term: flunitrazepam
Definition: A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Chemical ID: MESH:D005445
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabra1affects bindingEXP 6480464CTDFlunitrazepam binds to GABRA1 protein

PMID:8397295
Gabra1multiple interactionsEXP 6480464CTDalphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein] Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]

PMID:8397295
Gabra1affects bindingISORGD:7309026480464CTDFlunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]

PMID:22029276
Gabra1multiple interactionsISORGD:7309026480464CTD2 6-diisopropyl-4-3-3-methyl-3H-diazirin-3-ylpropylphenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein] Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

PMID:22029276 PMID:8632757
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