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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2254
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Calca
Name: calcitonin-related polypeptide alpha
Acc ID: CHEBI:31550
Term: epothilone B
Definition: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).
Chemical ID: MESH:C093788
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Calcadecreases expressionEXP 6480464CTDepothilone B results in decreased expression of CALCA protein

PMID:26883566
Calcamultiple interactionsEXP 6480464CTDepothilone B affects the reaction [[Capsaicin co-treated with NGF protein] results in increased secretion of CALCA protein], epothilone B inhibits the reaction [Potassium results in increased secretion of CALCA protein], epothilone B promotes the reaction [[Potassium co-treated with NGF protein] results in increased secretion of CALCA protein]

PMID:26883566
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.