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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:31549
Term: epothilone A
Definition: An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).
Chemical ID: MESH:C093787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISORGD:13464646480464CTDepothilone A results in increased expression of H2AX mRNA

PMID:29117515
H2axmultiple interactionsISORGD:13464646480464CTD[epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA

PMID:29117515
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.