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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10997
Species: Mus musculus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3, endothelial cell
Acc ID: CHEBI:31547
Term: eplerenone
Definition: A steroid acid ester that has formula C24H30O6.
Chemical ID: MESH:C414690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionISONos3 (Rattus norvegicus)6480464CTDeplerenone results in decreased expression of NOS3 mRNA; eplerenone results in decreased expression of NOS3 proteinPMID:20571278
Nos3increases activityISONos3 (Rattus norvegicus)6480464CTDeplerenone results in increased activity of NOS3 proteinPMID:15974890
Nos3increases expressionISONos3 (Rattus norvegicus)6480464CTDeplerenone results in increased expression of NOS3 mRNAPMID:15974890
Nos3multiple interactionsISONos3 (Rattus norvegicus)6480464CTD[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNAPMID:20571278
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