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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:31539
Term: epalrestat
Definition: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Chemical ID: MESH:C038131
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDepalrestat results in increased expression of SOD2 mRNAPMID:28204799
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDepalrestat analog inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; epalrestat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]PMID:37257577
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