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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:31530
Term: edaravone
Definition: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Chemical ID: MESH:C005435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPmultiple interactionsISOApp (Rattus norvegicus)6480464CTDEdaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA]PMID:26111763
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