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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733118
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:31530
Term: edaravone
Definition: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Chemical ID: MESH:C005435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2decreases expressionISOCxcl2 (Rattus norvegicus)6480464CTDEdaravone results in decreased expression of CXCL2 mRNAPMID:15948865
Cxcl2multiple interactionsISOCxcl2 (Rattus norvegicus)6480464CTDEdaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]PMID:12954792
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