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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315695
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C1
Name: aldo-keto reductase family 1 member C1
Acc ID: CHEBI:31527
Term: dydrogesterone
Definition: A 3-oxo Delta(4)-steroid that has formula C21H28O2.
Chemical ID: MESH:D004394
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C1decreases activityEXP 6480464CTDDydrogesterone results in decreased activity of AKR1C1 proteinPMID:21182831
AKR1C1decreases expressionEXP 6480464CTDDydrogesterone results in decreased expression of AKR1C1 mRNAPMID:23183084
AKR1C1increases expressionEXP 6480464CTDDydrogesterone results in increased expression of AKR1C1 mRNAPMID:23183084
AKR1C1increases metabolic processingEXP 6480464CTDAKR1C1 protein results in increased metabolism of DydrogesteronePMID:21182831
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