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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734051
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRA1D
Name: adrenoceptor alpha 1D
Acc ID: CHEBI:31515
Term: domperidone
Definition: 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Chemical ID: MESH:D004294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADRA1Daffects response to substanceEXP 6480464CTDADRA1D gene SNP affects the susceptibility to DomperidonePMID:21063774
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