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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732102
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Acc ID: CHEBI:31515
Term: domperidone
Definition: 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Chemical ID: MESH:D004294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 gene SNP affects the susceptibility to DomperidonePMID:21063774
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDDomperidone results in decreased activity of KCNH2 proteinPMID:15640612 PMID:28551711
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDDomperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]PMID:19583963
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