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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731284
Species: Homo sapiens
RGD Object: Gene
Symbol: HSD17B4
Name: hydroxysteroid 17-beta dehydrogenase 4
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSD17B4affects expressionEXP 6480464CTDColforsin affects the expression of HSD17B4 mRNAPMID:20726872
HSD17B4increases expressionEXP 6480464CTDColforsin results in increased expression of HSD17B4 mRNAPMID:16935330 PMID:22446829
HSD17B4multiple interactionsEXP 6480464CTDAminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B4 mRNA]PMID:16935330 PMID:20726872
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