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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10512
Species: Mus musculus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1decreases expressionISOEGR1 (Homo sapiens)6480464CTDColforsin results in decreased expression of EGR1 mRNA; Colforsin results in decreased expression of EGR1 proteinPMID:29802914
Egr1multiple interactionsISOEGR1 (Homo sapiens)6480464CTDColforsin inhibits the reaction [Ethanol results in increased expression of EGR1 mRNA]; Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 protein]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 mRNA]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 protein]PMID:29802914
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