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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10325
Species: Mus musculus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpamultiple interactionsEXP 6480464CTDColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA]PMID:17407152
Cebpaincreases expressionISOCebpa (Rattus norvegicus)6480464CTDColforsin results in increased expression of CEBPA proteinPMID:21832167
Cebpamultiple interactionsISOCebpa (Rattus norvegicus)6480464CTDColforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein]PMID:21832167
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