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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:31401
Term: cilostazol
Definition: A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Chemical ID: MESH:C045645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDcilostazol affects the expression of BAX proteinPMID:15978173
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCilostazol results in increased expression of BAX mRNA; Cilostazol results in increased expression of BAX proteinPMID:20131233 PMID:35920412
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Cilostazol co-treated with Meloxicam] results in increased expression of BAX mRNA; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]PMID:16822680 PMID:35920412
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