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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:31399
Term: cilnidipine
Definition: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Chemical ID: MESH:C065927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4increases activityISORGD:7341036480464CTDcilnidipine results in increased activity of NR1H4 protein

PMID:25257666
Nr1h4multiple interactionsISORGD:7341036480464CTDcilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] cilnidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] cilnidipine inhibits the reaction [pregna-4 17-diene-3 16-dione results in decreased activity of NR1H4 protein]

PMID:25257666 PMID:27773686
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