GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | increases phosphorylation | EXP | | 6480464 | CTD | Bleomycin results in increased phosphorylation of SMAD3 protein | PMID:27704718 PMID:32032644 PMID:35187969 | Smad3 | multiple interactions | EXP | | 6480464 | CTD | 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]; honokiol inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] | PMID:27704718 PMID:32032644 PMID:35187969 | Smad3 | increases expression | ISO | Smad3 (Rattus norvegicus) | 6480464 | CTD | Bleomycin results in increased expression of SMAD3 mRNA | PMID:26093215 | Smad3 | multiple interactions | ISO | Smad3 (Rattus norvegicus) | 6480464 | CTD | Phytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA] | PMID:26093215 | | ||||||||||||||||||||||
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