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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2multiple interactionsEXP 6480464CTD[Polyphenols co-treated with Bleomycin] results in increased expression of BCL2 mRNA; [Tea co-treated with Bleomycin] results in increased expression of BCL2 mRNAPMID:26800624
BCL2decreases expressionISOBcl2 (Mus musculus)6480464CTDBleomycin results in decreased expression of BCL2 proteinPMID:37783230
BCL2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDBleomycin results in decreased expression of BCL2 mRNAPMID:24822179 PMID:26093215
BCL2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDBleomycin results in increased expression of BCL2 proteinPMID:23656969
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTD5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of BCL2 mRNA]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of BCL2 protein]; Diazoxide inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]PMID:32278510 PMID:37783230
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD[Bleomycin co-treated with Bee Venoms] results in decreased expression of BCL2 mRNA; allyl sulfide promotes the reaction [Bleomycin results in increased expression of BCL2 protein]; Phytochemicals inhibits the reaction [Bleomycin results in decreased expression of BCL2 mRNA]PMID:23656969 PMID:24822179 PMID:26093215
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