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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7310146480464CTDBleomycin results in increased expression of CCN2 mRNA, Bleomycin results in increased expression of CCN2 protein

PMID:19080365, PMID:26817844
multiple interactionsISORGD:7310146480464CTD[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA], [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA], [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA], Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 mRNA], Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]

PMID:19080365, PMID:28434932
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.