GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ACTA2 | increases expression | EXP | | 6480464 | CTD | Bleomycin results in increased expression of ACTA2 mRNA; Bleomycin results in increased expression of ACTA2 protein | PMID:35267148 PMID:37898439 | ACTA2 | multiple interactions | EXP | | 6480464 | CTD | yupingfeng inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; yupingfeng inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] | PMID:37898439 | ACTA2 | decreases expression | ISO | Acta2 (Rattus norvegicus) | 6480464 | CTD | Bleomycin results in decreased expression of ACTA2 protein | PMID:34425168 | ACTA2 | increases expression | ISO | Acta2 (Mus musculus) | 6480464 | CTD | Bleomycin results in increased expression of ACTA2 mRNA; Bleomycin results in increased expression of ACTA2 protein | PMID:14609568 PMID:17177178 PMID:25648892 PMID:26520185 PMID:27153807 PMID:27704718 PMID:28694203 PMID:31302203 PMID:31901889 PMID:32032644 PMID:34153405 PMID:35187969 PMID:35279615 PMID:35472619 PMID:35716765 PMID:37399107 PMID:37783230 | ACTA2 | increases expression | ISO | Acta2 (Rattus norvegicus) | 6480464 | CTD | Bleomycin results in increased expression of ACTA2 mRNA; Bleomycin results in increased expression of ACTA2 protein | PMID:21381050 PMID:23656969 PMID:25582705 PMID:31706003 PMID:34425168 PMID:37163307 | ACTA2 | multiple interactions | ISO | Acta2 (Mus musculus) | 6480464 | CTD | (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of and results in increased phosphorylation of ACTA2 protein]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]]; [Arsenic Trioxide co-treated with Bleomycin] results in decreased expression of ACTA2 mRNA; [Bleomycin co-treated with Soot] results in increased expression of ACTA2 protein; Bleomycin results in increased expression of and results in increased phosphorylation of ACTA2 protein; Calcitriol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; celastrol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of and results in increased phosphorylation of ACTA2 protein]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; honokiol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; icaritin inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; loganin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; loganin inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of ACTA2 protein]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA] | PMID:14609568 PMID:17177178 PMID:24762191 PMID:26520185 PMID:27153807 PMID:27704718 PMID:28694203 PMID:31302203 PMID:31901889 PMID:32032644 PMID:34153405 PMID:35187969 PMID:35279615 PMID:35472619 PMID:35716765 PMID:37783230 | ACTA2 | multiple interactions | ISO | Acta2 (Rattus norvegicus) | 6480464 | CTD | allyl sulfide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; montelukast inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; pachymic acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] | PMID:21381050 PMID:23656969 PMID:25582705 PMID:31706003 PMID:37163307 | | ||||||||||||||||||||||
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