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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732102
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Acc ID: CHEBI:31264
Term: benzethonium chloride
Definition: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.
Chemical ID: MESH:D001558
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDBenzethonium results in decreased activity of KCNH2 proteinPMID:21362439 PMID:23313619 PMID:24052561
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTD[Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of ThalliumPMID:21362439
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