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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:31236
Term: aripiprazole
Definition: An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.
Chemical ID: MESH:C094645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2multiple interactionsEXP 6480464CTD[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to MethamphetaminePMID:17327886
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDAripiprazole binds to and results in increased activity of DRD2 proteinPMID:17069544
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