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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:31206
Term: ammonium chloride
Definition: An inorganic chloride having ammonium as the counterion.
Chemical ID: MESH:D000643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionEXP 6480464CTDAmmonium Chloride affects the expression of NFE2L2 mRNAPMID:16483693
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDAmmonium Chloride results in increased expression of NFE2L2 mRNAPMID:27867098
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Ammonium Chloride results in increased activity of NFE2L2 protein]; Ammonium Chloride results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]PMID:27867098
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