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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:31205
Term: amlexanox
Definition: A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Chemical ID: MESH:C045742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISORGD:107176480464CTDamlexanox results in increased expression of HMOX1 mRNA

PMID:31697998
Hmox1multiple interactionsISORGD:107176480464CTD[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA, amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein], dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA]

PMID:31697998
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.